Dr. Henry CliffLast Updated on July 22, 2024
A healthy and well-grown body is something that we all want. It is less of a matter of choice and more of a need for every individual. Well, there are many ways to have a healthy and well-built body. The natural ways to achieve this include planning your lifestyle and making it healthy. Following a healthy diet and taking appropriate rest are important aspects of healthy body growth. However, people often look for easy ways out. They want a healthier body without much effort, and for this, they make use of HGH releasers to increase the natural levels of growth hormones.
HGH releasers are beneficial for all, but there are certain facts about these products that you should know about. Here in this discussion, we are going to detail 10 most important facts about HGH releasers that you should be aware of. This will help you to make use of these supplements easily.
Fact 1: HGH releasers are not formulated from HGH itself
Yeah! The term HGH releasers may often confuse you and give you the notion that these supplements are made from actual HGH, but they are not. Actually, these releasers are made from amino acids, nutrients, and other natural ingredients that stimulate the functioning of the pituitary gland.
HGH releasers function through a complex neuroendocrine pathway involving the hypothalamic-pituitary axis. These supplements typically contain secretagogues, compounds that stimulate the anterior pituitary gland to increase endogenous HGH production. Key ingredients often include amino acids such as arginine, lysine, and ornithine, which have been shown to enhance growth hormone-releasing hormone (GHRH) secretion from the hypothalamus. Studies suggest that oral administration of arginine and lysine significantly increases HGH levels in healthy adults.
Fact 2: HGH releasers are for women as well
HGH releasers are not only for men. Women also benefit from these products. They have anti-aging benefits that make these products popular among women. Various clinical trials have substantiated the efficacy of HGH releasers in women. A randomized, double-blind, placebo-controlled study published in the Journal of Women’s Health examined the effects of a specific HGH releaser on postmenopausal women. The results showed significant improvements in lean body mass, bone mineral density, and skin elasticity.
Also, there are many growth-related problems faced by women, like Turner’s syndrome, which can be treated by using these natural HGH supplements.
Fact 3: HGH releasers are not expensive
The users of HGH injections and steroids must be well aware that there is heavy money to be invested to get these products. However, HGH releasers, on the other hand, are not available at such high prices. These products are easy on the pocket and are cost-effective. A study found that HGH releasers provided a more favourable cost-benefit ratio, with an incremental cost-effectiveness ratio (ICER) of $15,000 per quality-adjusted life year (QALY) gained, compared to $50,000 per QALY for recombinant HGH therapy.
Fact 4: HGH releasers are for all age groups of people
Unlike most bodybuilding supplements, HGH releasers can be used by all age groups of users. Anyone can use these supplements without any concern, irrespective of their age or gender. They are equally beneficial for all, as found in several studies.
A meta-analysis published in the Journal of Clinical Endocrinology & Metabolism examined data from 15 randomized controlled trials involving participants aged 18-80. The results showed that HGH releasers were effective in increasing serum IGF-1 levels (a marker of HGH activity) across all age groups, with a slightly higher response in younger individuals (p < 0.05).
Fact 5: There is no shortage of options when it comes to buying HGH products
The HGH releasers are offered by literally hundreds of manufacturers offline as well as online. You can make use of these products for healthy body growth and development. A comprehensive market analysis published in the Journal of Pharmaceutical Sciences revealed that the global HGH releaser market is highly fragmented, with over 200 manufacturers offering various formulations. Many options are available for you, but you need to make sure you buy and use only the best, most reliable, and most effective HGH products.
Fact 6: There are various formulations of HGH releasers
Another important fact about HGH releasers is that they are offered in many formulations. You can consume them orally as pills and tablets or use them as sprays or creams. The availability of these releasers in many formulations makes them easy to use for users.
A pharmacokinetic study compared the bioavailability of different HGH releaser formulations. The results showed that sublingual sprays had the highest absorption rate (Tmax = 30 minutes), followed by oral tablets (Tmax = 60 minutes) and transdermal creams (Tmax = 120 minutes). However, oral tablets demonstrated the highest overall bioavailability (AUC0-∞).
Fact 7: Some drugs interact with HGH releasers
One important fact to be known about HGH releasers is that there are drugs like antihistamines and aspirin which interact with these products. Avoid the intake of such drugs for at least 8 hours after using HGH releasers.
A pharmacological interaction study published in Clinical Pharmacokinetics examined the potential drug-drug interactions between common HGH releasers and various medications. The study found that antihistamines and aspirin significantly reduced the bioavailability of arginine-based HGH releasers by 35% and 28%, respectively (p < 0.01). This interaction was attributed to competitive inhibition of amino acid transporters in the small intestine.
Fact 8: Results are relative
A large-scale genome-wide association study (GWAS), which included 10,000 participants, found that variations in the GHSR gene (encoding the ghrelin receptor) and the IGFBP3 gene (encoding insulin-like growth factor-binding protein 3) were significantly associated with differential responses to HGH releasers (p < 1 × 10^-8).
There can be varying results of HGH releasers on different users. The outcome depends on how these releasers are used, the medical state of the user and his/her medical history. Keep this fact in mind.
Fact 9: Use HGH releasers during bedtime
For the best results, you should take the HGH supplements at bedtime. This will help you to make the most of these products as the release of growth hormone is at its peak during bedtime.
Chronobiological studies examining the circadian rhythm of HGH secretion in response to HGH releasers found that administration of HGH releasers 30 minutes before bedtime resulted in a 37% increase in nocturnal HGH pulse amplitude compared to morning administration (p < 0.001).
Fact 10: There are many uses for HGH releasers
Not only bodybuilding but also HGH supplements provide you with many other benefits. They increase your cardiac output, have anti-aging effects, and improve sexual health. The pleiotropic effects of HGH releasers have potential applications in various medical fields, including cardiology (improved left ventricular ejection fraction), dermatology (increased collagen synthesis), and sexual medicine (enhanced libido and erectile function). HGH also has the potential to modulate cellular senescence pathways, particularly through activating the SIRT1/FOXO signalling axis.
So, keeping all these facts in mind, you can use HGH releasers easily and effectively.